“The results unveils artists like ray lamontagne from this ray lamontaigne defines study demonstrate thatRAD001 has the potential to provide an effective new option for thesepatients.” A global Phase III clinical trial program to evaluate the efficacy and safetyof RAD001 monotherapy in approximately 500 advanced gastric cancer patientswill begin enrollment this year. “Most advanced gastric cancer patients eventually stop responding to currenttherapies, demonstrating a considerable need for new treatment options,” saidAlessandro Riva, MD, Executive Vice President & Global Head of Development,Novartis Oncology Ray Lamontagne concert tickets – amazon . “Early data show RAD001 may benefit these patients andprovides the rationale for additional studies. Novartis is committed tofurther exploring the potential of RAD001 for this hard to treat cancer, aswell as studying its role in treating other tumor types.”Gastric cancer, commonly referred to as stomach cancer, was diagnosed in21,500 Americans in 2008 and claimed the lives of more than 10,000 in the sametime period(2). This cancer is highly prevalent among people of Asian descent,with more than half of all new cases occurring in East Asia(3). It is believedthat the incidence is high among this population due in part to Helicobacterpylori infection and a diet high in smoked, salted or pickled foods Ray Lamontagne Ray Lamontagne concert tickets . Amongethnicities in the US, Asians and Pacific Islanders have the highest mortalityrates(4) Ray Lamontagne – last .Study detailsThe proof-of-concept, Phase II study is designed to assess the efficacy andsafety of RAD001 (10 mg) daily in patients with advanced gastric cancer(inoperable, recurrent or metastatic gastric cancer) whose disease progresseddespite prior treatment.

The primary endpoint of the study is to assessdisease control rate (DCR) be here now by ray lamontagne . Secondary endpoints included assessment ofobjective response rate (ORR), progression-free survival (PFS) and overallsurvival (OS), and to describe the safety profile of RAD001.The average duration of therapy was 57 days raycharles lamontagne . There was a DCR (completeresponse/partial response/stable disease) of 55% at eight weeks (95%Confidence Interval: 40.4 – 68.4%) ray lamontagne’s . Of the 53 patients evaluated for thestudy’s primary endpoint, 29 patients (55%) had stable disease, 22 (41%) hadprogressive disease and 2 (4%) had an unknown response The ORR was zero ray lamontagne’s wife Ray Lamontagne tickets – myspace . Themedian PFS was 83 days (95% Confidence Interval: 50 – 91 days), with 29.6% ofpatients estimated to still be progression-free at four months.

Median overallsurvival was not attained at the time of evaluation.The most commonly reported adverse events (all grades; >10% patients) in thestudy included, stomatitis, anorexia, fatigue, rash, nausea, edema peripheral,thrombocytopenia, diarrhea, pruritus, anemia, dysgeusia, vomiting, pyrexia,pneumonitis, constipation and insomnia be here now ray lamontagne movie . Serious adverse events (grade 3 or 4;>3% of patients) included anemia, hyponatremia, raised liver function,fatigue, stomatitis, anorexia, hyperglycemia, hypophosphatemia, ileus andlymphopenia.About RAD001 RAD001, an oral once-daily inhibitor of mTOR, is an investigational drug beingstudied in multiple tumor types ray lamontagne “let it be me . In cancer cells, RAD001 provides dailyinhibition of mTOR, a protein that acts as a central regulator of tumor celldivision, cell metabolism and blood vessel growth ray lamontagne “let it be . RAD001 is being studied in multiple cancer types including advanced kidney,breast and neuroendocrine tumors and lymphoma be here now lamontagne . Currently, RAD001 is underregulatory review in the US and Europe for the treatment of advanced renalcell carcinoma. The safety and efficacy profile of RAD001 has not yet been established inoncology and there is no guarantee that RAD001 will become commerciallyavailable for oncology indications.

The active ingredient in RAD001 iseverolimus, which is available in different dosage strengths under the tradename Certican(R) for the prevention of organ rejection in heart and kidneytransplant recipients Certican was first approved in the EU in 2003 . Certicanis not approved in the US.DisclaimerThe foregoing release contains forward-looking statements that can beidentified by terminology such as “promising,” “will,” “potential,” “may,”"committed,” “exploring,” “believed,” “estimated,” “anticipated,” or similarexpressions, or by express or implied discussions regarding potentialregulatory filings or marketing approvals for RAD001 or regarding potentialfuture revenues from RAD001 trouble lamontagne . You should not place undue reliance on thesestatements.Such forward-looking statements reflect the current views ofmanagement regarding future events, and involve known and unknown risks,uncertainties and other factors that may cause actual results with RAD001 tobe materially different from any future results, performance or achievementsexpressed or implied by such statements shelter lamontagne . There can be no guarantee that RAD001will be approved for sale for any oncology indication in any market . Nor canthere be any guarantee that RAD001 will achieve any particular levels ofrevenue in the future. In particular, management’s expectations regardingRAD001 could be affected by, among other things, unexpected regulatory actionsor delays or government regulation generally; unexpected clinical trialresults, including unexpected new clinical data and unexpected additionalanalysis of existing clinical data; the company’s ability to obtain ormaintain patent or other proprietary intellectual property protection;competition in general; government, industry and general public pricingpressures; the impact that the foregoing factors could have on the valuesattributed to the Novartis Group’s assets and liabilities as recorded in theGroup’s consolidated balance sheet, and other risks and factors referred to inNovartis AG’s current Form 20-F on file with the US Securities and ExchangeCommission.

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